That strip sends audio to my headset and to virtual out 'B3', which I use in fldigi and so on.

VAIO 3: that's my SDR channel, as you can tell by the two icons. Wife wants to listen, too? Just add 'A3' to send Skype sound to headset AND my PC speakers. You guessed right, that's incoming audio from Skype going to my headset. Voicemeeter Aux with 'A2' as only output, being my headset (and default communications device under Windows). Voicemeeter Vaio, my default sound device under Windows, for general audio purposes second input is the microphone of my headset, which goes to 'B2', the second virtual channel, routing my mike to Skype. Using Voicemeeter allows me to select which input I want to stream to the DAC. I could have used the DAC directly in my audio player, but then again I sometimes want to use the DAC with my AKG K701 connected to it for listening to something else. first input is my VBCable out (yes, you can pipe VBCable into Voicemeeter) for listening to 96kHz audio via my USB ODAC (first hardware output, note the green 'A1' button on the first strip). You can configure a complex matrix of input and output routing, so you could use one virtual channel for Skype (headset mike in/ headset out), another one for SDR, and a third channel for listening to music only, or any combination desired.

Are you saying that VoiceMeeter totally replaces the Windows audio mixer?Yes, kind of.

Voicemeeter virtual cable